NAC – (Replaces Can-C eye drops)
NAC Eye Drops have been hailed as a major breakthrough in the treatment of senile cataracts. They are n-acetylcarnosine eye drops (NAC) – a powerful anti-ageing oxidant that has proven benefits to cataract suffers. As the leading brand of cataract drops, NAC Eye Drops offer a tried and tested alternative to surgery in the treatment of senile cataracts.
How Does NAC Work? NAC contains a synthesised formulation of the anti-oxidant carnosine known as n-acetylcarnosine (NAC). NAC is based on the naturally occurring nutrient di-peptide carnosine (a combination of two amino-acids, or protein fragments). It is the key ingredient in NAC cataract eye drops due to NAC’s potency at ‘mopping up’ free radicals. As the root of tissue damage and accelerated ageing in our bodies, free radicals are the main culprit behind the cataract condition. NAC eye drops for cataracts contain NAC due to its robust characteristics. This is because carnosine’s ability to tackle free radicals and cataracts is blunted by the natural enzymes in the eye breaking carnosine down. However, NAC is highly resistant to this breakdown which, combined with the slow release characteristics of NAC n-acetylcarnosine eye drops, makes them highly effective in the treatment of cataracts.
NAC carnosine eye drops also tackle the bodily process of glycation (also known as cross-linking) – another key factor behind ageing and the development of cataracts. This is where glucose leads to changes and a hardening of tissues over time. NAC cataract eye drops deliver a powerful anti-oxidant boost to the eye – counteracting the natural decline of anti-oxidants as we grow older – to protect the eye lens proteins from free-radical induced deterioration.
What’s The Story Behind NAC?
The breakthrough behind NAC and the introduction of n-acetylcarnosine eye drops took place in the early 1990s, with landmark research by the bio-physicist Dr Mark Babizhayev and a Russian research team.
Human trials on cataract sufferers, involving a twice daily dose of NAC formulated drops over a period of six months, produced remarkable results. The research revealed that:
88.9 per cent of patients had improved glare sensitivity (which is a general decline in the sharpness of objects and surroundings –things literally becoming a bit fuzzy around the edges);
90 per cent reported improved visual acuity – clearer and sharper vision;
Perhaps most significantly, in that cataracts are characterised by a clouding of the eye lens, 41 per cent of patients experienced a significant improvement in lens ‘transmissivity’.
And while the patients were taking the NAC carnosine eye drops, Dr Babizhayev noted that there was no recurrence of cataract development. He further reported that drug tolerance was good - there were no side effects, based on the dosage of 1% NAC.
How Big is The Cataract Problem?
Cataracts are inextricably linked with the ageing process. As we grow older, our eye lenses have a tendency to become hard, opaque and cloudy. Less light reaching the centre of the eye affects our vision and over time, without treatment, can result in sight loss and eventual blindness.
Cataracts are a global concern – around 3.8 million people in India alone lose their sight to the condition every year, with an estimated 5 million worldwide.
Cataract surgery is a widely used and safe solution. In fact there are more than one million cataract operations each year in the US alone.
While a trusted and sound solution, it is still, nonetheless, a surgical procedure - carrying with it inherent risks (however small). For example in the United States 30% to 50% of all patients that have cataract surgery, develop opacification of the posterior lens capsule and require further lazer treatment.
Aside from this the potential costs of surgery are high (around $3500 per eye for cataract surgery in the US).
Why The NAC Brand?
NAC’s formula is the one perfected and patented by Dr Babizhayev and his team – who tried, tested and rejected many other forms of carnosine during their extensive research.
Only NAC contains these precise formulations of n-acetylcarosine and other key ingredients, making it such a powerful ally in the non-surgical, non-invasive treatment of cataracts.
Using N-acetylcarnosine Cataract Eye-drops
N-acetylcarnosine eye-drops have been shown to have measurable affects within only 1-month of use. However, it is recommended that for maximum efficacy, that administration be continued for a period not less than 3-5 months. In addition, the drops’ effectiveness is increased the sooner they are used after a cataract is detected.
Also, considering that senile cataracts are an on-going aging disorder. N-acetylcarnosine may be required on a regular basis to help maintain the eye's natural anti-oxidant defenses.
Frequently Asked Questions About NAC™
Disclaimer: Please note that only your own physician can determine your precise needs, but in order to give you some information these answers are based upon the ‘average person’ and clinical/ published results.
NAC be taken in conjunction with other common eye supplements such as lutein and zeaxanthin/astaxanthin?
We do not recommend that the NAC eye-drops are combined with lutein (unless a patient has a cataract associated with a retinal disorder), this is because lutein appears to block the receptor sites and may lower the efficacy of the results. You should stop taking lutein for at least the first 6 months but that after this period they may be started again. This is because NAC does the majority of its restorative work in that period and thereafter it is maintenance, thus a reduced efficacy is not so essential.
The same is true for zeaxanthin; however we are not aware of contraindications with astaxanthin.
Can one eat spirulina and other superfoods when using NAC? Are they considered foods or supplements, with problems similar to other caretenoids when using NAC?
The only known contraindication is with lutein competing with the same receptors in the eye as the n-acetylcarnosine. This does not mean that the combined intake of lutein with use of NAC Eyedrops would invalidate the effectiveness, but it’s efficacy could be reduced which may mean a longer treatment time.
Are there any problems using NAC concurrently with Xalatan® eye-drops for glaucoma pressure control? Would you recommend use of both?
To date there have been no noted contraindications or side effects noted with the use of other eye-drops combined with NAC™, but naturally as there are so many versions, not all eye-drops have been tested along with the same. The inventor of the technology has stated that beta blocker eye-drops used for glaucoma may actually have additional benefit when combined with NAC to help further reduce the intraocular pressure.
How long has NAC has been on the market?
NAC has been sold since 2001 and in that time has helped thousands of people cure their senile cataracts without painful surgery. In fact it is estimated that there have been 50,000 documented patient cases of NAC use.
Can I continue to use vitamin A and E supplements whilst using NAC?
It is the inventor's assertion that certain substances, including vitamins A and E inhibit the conversion process of the NAC into L-carnosine INSIDE the aqueous humor of the eye. He does not endorse them - rather the opposite (at least when used topically, however if vitamin A or E are taken orally there is no contraindication).
It is interesting to note that the copycat products have now stopped adding A and E to their formula, they simply do not understand how this technology performs.
Why does the NAC packaging say it is an eye lubricant rather than a treatment for cataract?
NAC™ is packaged for relief of dry eyes; it is not an approved drug to ‘treat cataracts’ in the eyes of the FDA. The suggestion refers to the uses and clinical trials that the Russians have performed.
NAC is not approved as a drug by the FDA because no submission has been made to do so, the requirements for drug approval are so costly that a molecule patent is required beforehand, as NAC is a natural product, it is extremely difficult to obtain a patent for a natural molecule and hence the process doesn't get started.
The source of the N-acetylcarnosine in NACis unique. It is made to a very specific purity in Japan and is the one used in the clinical trials. This is because the Russians found that only a specific purity value was efficacious, this source is only available in NAC.
For further information please read www.nacetylcarnosine.com which highlights many of the issues mentioned here. Also the international patents are now in force in the USA as of December 2010.
Are NAC eye drops ok for vegans?
There are no animal ingredients in NAC eye drops, all are 100% plant based; therefore the product is suitable for both vegetarians and vegans.
Do NAC eye drops work for other eye conditions?
Open-angle primary glaucoma
NAC eye-drops have been recommended by the inventors has suggested that it is a useful adjunct in the condition of open angle glaucoma. Although not proven, it is believed that the anti-glycosylation properties of NAC reduce the accumulation of proteins from around the schlemm canal (the valve in the eye), thus over time precipitating a release of pressure in the eye by allowing more waste materials to pass through into the bloodstream.
We don’t have any clinical evidence for floaters. NAC™ eye-drops have been successful in a number of other applications- other than cataract, but unfortunately floater’s is not one of them.
At present the clinical trials have focused on cataracts of the senile type - perhaps because they are the most common. At present there is anecdotal evidence to support role in other cataracts and aging eye disorders, perhaps because the delivery of carnosine is a natural defence mechanism inside the eye. The inventor of the technology does predispose that NAC will be effective for other cataracts; details have been noted inside the book ‘the cataract cure’ by Marios Kyriazis, M.D.
My optician says that my cataract is worse than last time but I can see better, how is this possible?
We are finding that in some cases that the cataract after treatment approximately the same size or in some cases is perceived as larger. This may be because the action of the drops is upon the crystallins within the lens, effectively making them clearer, whilst not perhaps reducing the amount/ size of the cataract.
Normally most patients will see an improvement of glare sensitivity (usually stated as improvements to night driving), then enhanced color perception and of course the ability to read additional lines on an eye chart, a clear sign of improving eye sight.
Effectively it can take several more months (in some cases) to actually reduce the size of the cataract, please note that the addition of NAC™ Plus, the new oral formula, can be taken alongside the eye-drops to help speed up this process.
Can a person who is diabetic use the NAC?
Yes, in fact the inventor recommends them for diabetic retinopathy.
Is it safe and appropriate that a person use NAC after they have already had cataract surgery?
Yes! Although it will not affect the replacement lens as that is made of plastic, however NAC™ can support the eye in other ways to ensure that other deterioration is avoided or at least delayed.
Many patients who are using NAC™ in this way, as there is no deterioration to the plastic of the artificial lens and NAC’s actions can help to maintain other eye structures - in our opinion its use is still worthy in such cases.
Will NAC eye drops work even though I wear contact lenses?
Yes in fact they can benefit contact lens wearing in 2 ways, firstly they inhibit the accumulation of lactic acid, thereby reducing the pain associated with contacts and secondly the lubricants in NAC™ make wearing the contacts more comfortable.
One thing we would recommend is that contacts be removed as normal, the eye washed with cold water and gently dabbed dry and then apply the NAC™ and wait 15-minutes (this gives the eye-drop time to pass through the membranes and enter the eye) before replacing the contact lens as normal. Note that although this is not an essential requirement, it may be beneficial to do so.
NAC be used to treat cataracts in dogs and other pets?
Yes, NAC has been effectively tested on dogs and rabbits. In fact because these animals lack an enzyme called carnosinase (which is found in humans) the drops actually work much faster. This is because the lack of carnosinase means that more of the active ingredient enters the eye and therefore more of the active ingredient is delivered. The only drawback is that administering the drops to animals may mean more loss as the animal blinks or shakes it head etc. But the bottom line is that NAC is known to improve the dog’s vision when applied daily for several weeks.
Has NAC’s Ph level changed and what effect will that have?
The Ph of NAC™ has been changed from early setting of 6.5 to 6.8 whilst technically there is a minute reduction in the uptake of the n-acetylcarnosine this has not in any way reduced the efficacy of NAC eye-drops. It just means that NAC is a much more comfortable product to use compared to other NAC containing products on the market, reducing the potential of stinging effects from 1 in 7 persons to 1 in 700 persons, so NAC is less likely to generate this uncomfortable side effect than other copycat products.
How do I store NAC eye drops?
NAC is stable for lengthy periods at room temperature, although at home we recommend that you keep them in the warmest part of the fridge (i.e. the door). This is especially true with opened bottle’s which should be discarded 28 days after opening (but if you are using the drops every day as recommended the bottle will be empty after 14 days).
NAC be damaged if it is frozen in transit?
It is possible that some damage will have occurred and we do not recommend that the product be frozen. The issue may be the loss of some efficacy however it does not mean that the properties of the product are completely lost.
How is NAC delivered into the eye?
The lens itself is inside the eye, floating in a liquid called the aqueous humour, the outer part of the eye (the part you can touch) normally inhibits absorption, but NAC has been specially designed to pass through the outer membranes and deliver carnosine into the fluid of the eye, thus making contact with the lens and helping to prevent glycosylation, the process that clouds the crystallins in the lens etc.
Do NAC eye drops have any influence on eye pressure?
All the current clinical trial support that in the majority of cases that NAC lowers the intraocular pressure, we have not heard reports of increased pressure to date. Officially the trials have been conducted in cataracts, specifically senile cataracts, however as has been made clear in Dr. Marios Kyriazis book ‘the cataract cure, the story of n-acetylcarnosine’ there have been a number of other noted improvements including some reduction in the intraocular pressure of the eye and we have received a number of statements to that affect also.
What standard is NAC manufactured to?
NAC is made from approved raw materials of pharmaceutical standard (made in Japan) and processed by cGMP and ISO9001 standards. NAC is the only drop that is approved, tested, patented and recommended by the inventors IVP.
Where can I read clinical studies about NAC and N-acetylcarnosine?
I am basically healthy elderly. I have mild cataracts AND early-stage dry AMD.
Have read your materials extensively, I realize that with NAC, most emphasis is on support for cataracts but that it does support "other eye conditions." QUESTION 1: Are you aware of any potential negative effects to AMD condition if taking NAC for cataracts? QUESTION 2: Should I add aminoguanidine? QUESTION 3: Should I add metformin, even though I’m not diabetic? Many thanks for excellent website and for your reply.
Yes NAC can assist aging eyes for many other types of disorders, but it is not clear if it can be truly successful in AMD. You need to know about the melatonin trial with AMD see here: http://www.antiaging-systems.com/132-melatonin-zn-se
My son, age 32, is suffering from retinitis pigmentosa. As a result, in recent years he has developed a subcapsular posterior cataract. I would avoid him from cataracts surgery, in reason of possible complications on RP. Are your eye drops useful for this purpose?
It’s possible that it could help, it has been useful with many different forms of cataract; much depends on how long your son has had this cataract, with the shorter time the better. To be sure of effectiveness it is best to use the drops (2 into the affected eye twice a day) for a period of 3-5 months, hopefully some improvement may be noted much quicker, look for signs such as improved reading of eye-chart, better color perception or improved night glare (for example looking at car lights).
I am very encouraged by what I have read about NAC eye drops, both journal articles and patient testimonials, and I have a question: I developed a cataract in one eye as a result of a vitrectomy procedure required for a detached retina one year ago. Is NAC appropriate for this type of cataract condition or just senile cataracts?
There’s no reason to presume that NAC won’t be effective for any form of cataract, whilst the clinical data surrounds senile cataracts, over the years we have received much anecdotal evidence for many other kinds of cataracts and indeed eye disorders. It is no accident that the eye naturally uses carnosine in its defence mechanism and ergo replacing it as it declines with age helps to support its natural defences, there is a lot of technical data to be see at www.nacetylcarnosine.com
I need to know if there is a limit to how long one uses NAC. I have been using it to control or eliminate cataracts and it seems to help with my dry eyes. Please advise me if it is okay to use indefinitely, or if I should limit its use. I use one drop in each eye, twice a day. I have been following this regimen for about 2 years.
As you probably know the clinical trials were conducted for 2-years and there were no signs of any issues in that time. We have clients who have been using it (and monitoring it) for more than 3-years, again in these cases there have been no complaints and a continuing benefit.
It is our belief that because NAC contains natural ingredients, many of which the eye uses in its own defence, that they can be used for very long periods as an antiaging guard. As you are using the maintenance dose this seems practical, it could be possible for you to reduce it to just 1-drop once a day.
I have gone through cataract surgery many years ago and I am wondering how can the NAC solution pass through the plastic lens implanted in my eyes and deliver the beneficial effects of the eye drop to the eyes.
The lens floats in the liquid of the eye called the aqueous humor, therefore it doesn’t act as a block to tissues behind it. We have a number of people with artificial lenses using NAC and there have been no complications noted to date.
As a preventative measure, two drops into both eyes once a day may be a suitable on-going regime. As for treatment, two drops into the affected twice daily is the ideal regime- there is no benefit in exceeding this dose. It is recommended that occasional use of N-acetylcarnosine eye-drops continue even after the reduction/reversal of the cataract to prevent any re-occurrence.
To date, no serious side effects or contraindications have been noted in any of the clinical trials.